Lead: Painting an Epidemic

نویسنده

  • Ron Chepesiuk
چکیده

The worldwide obesity epidemic is usually blamed on overeating and underexercising. But limited evidence has suggested a few environmental contaminants may also be playing a role. Now some of the first detailed evidence implicating organotins, a class of persistent compounds containing at least one tin–carbon bond, has been published in the September 2006 Molecular Endocrinology. A team of U.S. and Japanese researchers found both in vitro and in vivo evidence that exposure to a number of organotins, at concentrations typically found in people and wildlife, can contribute to alterations in pathways known to play a key role in excess weight gain, and can lead to significant aberrations in fat cells in mice and frogs. As in many countries around the world, the percentage of people in the United States who are overweight and obese has been rising sharply in the past 30 years or so. Excess weight is strongly linked with many serious health problems, including heart disease, type 2 diabetes, high blood pressure, and some cancers. Prevention of obesity is by far the best available treatment. Preventing exposures to environmental contaminants over the course of a lifetime, even prior to conception, may be an important part of the battle, if this and other recent papers hold up to scrutiny. Bruce Blumberg, an assistant professor of developmental and cell biology at the University of California, Irvine, and his colleagues studied organotins partly because of their endocrine-disrupting effects. Growing evidence suggests that some endocrine dis-ruptors (such as bisphenol A and nonyl-phenol) can play a role in weight gain (although others, such as genistein, can protect against weight gain). Organotins are widespread through their use in boat hull antifouling paints, pesticides, wood preservatives , textiles (as a biocidal agent), plastics, and other products. Many studies have documented adverse health and environmental effects of organotins, from masculinization in some fish to hepatotoxicity in some mammals. Human exposure is largely through consumption of contaminated foods and contact with treated materials. The team assessed several organotins to gauge their effects on weight gain, and found that a few, particularly tributyltin chloride, were strongly implicated. Others, such as bis(triphenyltin) oxide, dibutyltin, tetrabutyltin, and the dialkyltins, also showed some effects. To varying degrees, in vitro and in vivo exposures in mice and frogs disrupted the normal function of retinoid X receptor α, β, and γ and/or peroxisome pro-liferator–activated receptor γ, all of which play key roles in …

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عنوان ژورنال:

دوره 114  شماره 

صفحات  -

تاریخ انتشار 2006